Lenvatinib halts aortic aneurysm growth by restoring smooth muscle cell contractility
نویسندگان
چکیده
منابع مشابه
Genetics of thoracic aortic aneurysm: at the crossroad of transforming growth factor-β signaling and vascular smooth muscle cell contractility.
Aortic aneurysm, including both abdominal aortic aneurysm and thoracic aortic aneurysm, is the cause of death of 1% to 2% of the Western population. This review focuses only on thoracic aortic aneurysms and dissections. During the past decade, the genetic contribution to the pathogenesis of thoracic aortic aneurysms and dissections has revealed perturbed extracellular matrix signaling cascade i...
متن کاملSuperoxide anion impairs contractility in cultured aortic smooth muscle cells.
We examined the effects of superoxide anion (O) generated by xanthine plus xanthine oxidase (X/XO) on the intracellular Ca(2+) concentration ([Ca(2+)](i)) and muscle contractility in cultured bovine aortic smooth muscle cells (BASMC). Cells were grown on collagen-coated dish for the measurement of [Ca(2+)](i). Pretreatment with X/XO inhibited ATP-induced Ca(2+) transient and Ca(2+) release-acti...
متن کاملSmooth muscle cell-specific Tgfbr1 deficiency promotes aortic aneurysm formation by stimulating multiple signaling events
Transforming growth factor (TGF)-β signaling disorder has emerged as a common molecular signature for aortic aneurysm development. The timing of postnatal maturation plays a key role in dictating the biological outcome of TGF-β signaling disorders in the aortic wall. In this study, we investigated the impact of deficiency of TGFβ receptors on the structural homeostasis of mature aortas. We used...
متن کاملCharacterizing Aortic Smooth Muscle Cell Phenotype in the Setting of Thoracic Aortic Aneurysm
INTRODUCTION Bicuspid aortic valve disease (BAV) is the most common congenital cardiac malformation occurring in 1-2% of the general population [1] [2]. Normally, the aortic valve is separated into 3 valves. However, BAV involves fusing of the valvular leaflets during development, resulting in a 2-valve structure instead of the normal 3-valve structure. BAV predisposes patients to a thoracic ao...
متن کاملOverexpression of transforming growth factor beta1 in smooth muscle cells of human abdominal aortic aneurysm.
OBJECTIVE to examine the expression of transforming growth factor beta1 (TGF-beta1) and the cell kinetics of smooth muscle cells (SMCs) at the neck of abdominal aortic aneurysms (AAAs). MATERIALS AND METHODS expression of alpha-smooth muscle actin and TGF-beta1 was evaluated by immunostaining, and cell kinetics were estimated by terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick ...
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ژورنال
عنوان ژورنال: JCI Insight
سال: 2021
ISSN: 2379-3708
DOI: 10.1172/jci.insight.140364